Polyethylene glycol, unique among laxatives, suppresses aberrant crypt foci, by elimination of cells
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منابع مشابه
Polyethylene glycol, unique among laxatives, suppresses aberrant crypt foci, by elimination of cells.
OBJECTIVE Polyethylene glycol (PEG), an osmotic laxative, is a potent inhibitor of colon cancer in rats. In a search for the underling mechanisms, the hypothesis that fecal bulking and moisture decrease colon carcinogenesis was tested. We also investigated the PEG effects on crypt cells in vivo. MATERIAL AND METHODS Fischer 344 rats (n=272) were injected with the colon carcinogen, azoxymethan...
متن کاملPolyethylene glycol, unique among laxatives, suppresses aberrant crypts foci, by elimination of cells
Background: Polyethylene glycol (PEG), an osmotic laxative, is a very potent inhibitor of colon cancer in rats. In a search for mechanisms, we tested the hypothesis that fecal bulking and moisture decreases colon carcinogenesis. We also looked for PEG effects on crypt cells in vivo. Methods: Fischer 344 rats (N=272) were given an injection of the colon carcinogen azoxymethane. They were then ra...
متن کاملPolyethylene-glycol suppresses colon cancer and causes dose-dependent regression of azoxymethane-induced aberrant crypt foci in rats.
Dietary polyethylene-glycol (PEG) 8000, a nonfermented polymer laxative, strongly suppresses azoxymethane-induced aberrant crypt foci (ACF) in the colon of rats, as shown in a previous study (D. E. Corpet et al., Carcinogenesis (Lond.), 20: 915-918, 1999). In the present study, we tested the effect of PEG administered during either initiation or postinitiation, the dose-response effect of PEG, ...
متن کاملAberrant Crypt Foci in Rats Dose-dependent Regression of Azoxymethane-induced Polyethylene-glycol Suppresses Colon Cancer and Causes
Dietary polyethylene-glycol (PEG) 8000, a nonfermented polymer laxative, strongly suppresses azoxymethane-induced aberrant crypt foci (ACF) in the colon of rats, as shown in a previous study (D. E. Corpet et al., Carcinogenesis (Lond.), 20: 915–918, 1999). In the present study, we tested the effect of PEG administered during either initiation or postinitiation, the dose-response effect of PEG, ...
متن کاملPolyethylene-glycol, a potent suppressor of azoxymethane-induced colonic aberrant crypt foci in rats.
Bulking fibers and high water intake may decrease colon carcinogenesis in rats, and the risk of colorectal cancer in humans. We speculated that a non-fermented polymer, polyethylene-glycol (PEG) 8000, which increases stool moisture, might protect rats against colon carcinogenesis. Thirty female F344 rats were given a single injection of azoxymethane (20 mg/kg), and 7 days later randomized to AI...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Gastroenterology
سال: 2006
ISSN: 0036-5521,1502-7708
DOI: 10.1080/00365520500380668